Drug Release Characteristics and Tissue Distribution of Rifapentine Polylactic Acid Sustained-Release Microspheres in Rabbits after Paravertebral Implantation
نویسندگان
چکیده
منابع مشابه
drug release characteristics and tissue distribution of rifapentine polylactic acid sustained-release microspheres in rabbits after paravertebral implantation
conclusions after paravertebral implantation of rifapentine polylactic acid sustained-release microspheres, the concentration of rifapentine in local vertebral bone tissues was maintained above the tb minimum inhibitory concentration for up to 60 days with no apparent accumulation of the drug in other tissues. methods this study is a basic animal experimental study that began on july 17, 2014 i...
متن کاملDrug Release Characteristics and Tissue Distribution of Rifapentine Polylactic Acid Sustained-Release Microspheres in Rabbits after Paravertebral Implantation
BACKGROUND Rates of drug-resistant tuberculosis (TB) and TB associated with human immunodeficiency virus (HIV) infection have increased dramatically, intensifying challenges in TB control. New formulations of TB treatment drugs that control drug release and increase local drug concentrations will have a significant impact on mitigating the toxic side effects and increasing the clinical efficacy...
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ژورنال
عنوان ژورنال: Iranian Red Crescent Medical Journal
سال: 2016
ISSN: 2074-1804,2074-1812
DOI: 10.5812/ircmj.38661